Dual CAR
Dual CAR is designed with objective to lower relapse rate and provide better safety profile.
Clinical trials have demonstrated that sequential treatment with another CAR-T targeting 2nd antigen is able to control disease relapse.
Dual CARs may be able to enhance efficacy by reducing relapse resulted from antigen escape.
Stimulated by two CARs, CAR-T cells can be maintained in vivo longer than traditional single CAR.